One of the Largest Studies in Adults 75 Years or Older

PREVENTABLE is one of the largest research studies in older adults. The purpose is to learn if taking a statin could help older adults live well for longer by preventing dementia, disability, or heart disease. A statin is a commonly used drug to lower cholesterol.

Understanding how to PREVENT dementia in Older Adults

Watch this video to learn more about PREVENTABLE and how you can be a research hero for dementia prevention.

Understanding how to PREVENT dementia in Older Adults (English)

Watch this short video (3 mins)

Comprendiendo cómo PREVENIR la demencia en adultos mayores (Español)

Mira este breve video (3 mins)

Hear from Older Adults about PREVENTABLE

Study participant advisors share why they are excited about PREVENTABLE and why they think this study is important for older adults.

Who is Involved in PREVENTABLE?

About 20,000 older adults along with a team of researchers, clinicians, participant advisors, and community partners.
The study receives funding from the National Institute on Aging (NIA) and the National Heart Lung Blood Institute (NHLBI), which are both part of the National Institutes of Health (NIH).

The VA PREVENTABLE Network, a group of Veterans Administration(VA) medical centers across the country, is a very proud partner in this trial with over 50 participating enrollment sites. If you are a veteran and are interested in learning more about this trial, please click here to locate the closest participating VA Medical Center to you.

Cognitive and Physical Function

Learn more about the cognitive and physical function tests used in PREVENTABLE. Information from these assessments show researchers how the brain is working without having to do fancy, expensive tests such as an MRI or a CAT scan.


Researchers and doctors at 100 health systems across the United States are participating in the PREVENTABLE study.

The health systems include the Veterans Affairs and institutions that are part of PCORnet®, The National Patient-Centered Clinical Research Network.
Check the STUDY LOCATIONS menu item above to see a detailed list of health systems that are participating in PREVENTABLE. You can speak with your clinician about PREVENTABLE.

How is PREVENTABLE Different?

PREVENTABLE is considered a pragmatic study. Pragmatic studies make participating in research easy by using new methods to connect researchers with participants where they live and on their schedule. Pragmatic studies also test if a drug has the expected effects rather than how it works.

Pragmatic studies like PREVENTABLE are particularly ideal for older adults. We will follow study participants by reviewing their health records and through a phone call or a home visit. We will also mail study drug directly to a participant's home.

Quotes about PREVENTABLE
Research Sponsor

The National Institute on Aging ( is an institute of the NIH, a U.S. Federal Government agency that provides accurate, up-to-date information about aspects of aging research, information about clinical trials, educational materials and resources about aging for the general public, and information for researchers and health professionals.